Postdoctoral Research Scientist

Postdoctoral Research Scientist This post will investigate how Parkinson's disease-associated genetic perturbations alter mitochondrial function and cellular metabolism in human neurons. The postholder will extend, quality-control and use focused CRISPRi/a sgRNA libraries in iPSC-derived cortical neurons and validate priority findings in iPSC-derived dopaminergic neurons. Cellular responses will be characterised using established high-content imaging, quantitative cellular phenotyping and assays of neuronal metabolism, under the supervision of Dr Brent Ryan in the Department of Physiology, Anatomy and Genetics. The successful candidate will be based in the Ryan Group within the Laboratory of Molecular Neurodegeneration at the Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford.