Characterization and modelling of particle flow properties

Processes such as hot ‑ melt extrusion (HME) and twin ‑ screw melt granulation (TSMG) are widely used in the pharmaceutical industry to continuously produce high value ‑ added products. In HME, a powdered mixture containing the drug and an appropriate polymer is processed to form an amorphous solid dispersion with improved drug solubility.